Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

428020

Sigma-Aldrich

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem®

Sinónimos:

Latrunculin B, Latrunculia magnifica

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C20H29NO5S
Número de CAS:
76343-94-7
Peso molecular:
395.51
MDL number:
MFCD00270879
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Latrunculin B, Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white to yellow

solubility

DMSO: 25 mg/mL
ethanol: 25 mg/mL
methanol: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1

InChI key

NSHPHXHGRHSMIK-JRIKCGFMSA-N

General description

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.
A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes; 10 to 100-fold more potent than cytochalasins.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Actin polymerization
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful (C)

Other Notes

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Giovanni Stefano et al.
Methods in molecular biology (Clifton, N.J.), 2177, 23-33 (2020-07-08)
The endoplasmic reticulum (ER) is one of the most abundant endomembrane compartments and is in close association with most of the other organelles. In mammalian and yeast cells, the physiological roles and the molecular machineries underlying such association have only
Hanumanthu Bd Prasada Rao et al.
eLife, 10 (2021-09-30)
During meiosis, protein ensembles in the nuclear envelope (NE) containing SUN- and KASH-domain proteins, called linker nucleocytoskeleton and cytoskeleton (LINC) complex, promote the chromosome motion. Yeast SUN-domain protein, Mps3, forms multiple meiosis-specific ensembles on NE, which show dynamic localisation for
Antonios Georgantzoglou et al.
The Journal of cell biology, 221(8) (2022-06-23)
Migrating cells must interpret chemical gradients to guide themselves within tissues. A long-held principle is that gradients guide cells via reorientation of leading-edge protrusions. However, recent evidence indicates that protrusions can be dispensable for locomotion in some contexts, raising questions
Leila Taher et al.
Scientific reports, 11(1), 23731-23731 (2021-12-11)
Superovulation is the epitome for generating oocytes for molecular embryology in mice, and it is used to model medically assisted reproduction in humans. However, whether a superovulated oocyte is normal, is an open question. This study establishes for the first
Microtubule retrograde flow retains neuronal polarization in a fluctuating state.
Schelski, et al.
Science Advances, 8, eabo2336-eabo2336 (2022)
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico