251700

1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride

Effective irreversible inhibitor of uPA, Factor Xa, and urokinase.

• Sinónimos: 1,5-DNS-GGACK, 2HCl
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: off-white
• shipped in: ambient
• storage temp.: 2-8°C

Descripción

General description

Effective irreversible inhibitor of uPA, Factor Xa, and urokinase. Fluorophore allows direct monitoring of interactions of labeled enzyme. Does not inhibit tPA.

Biochem/physiol Actions

Cell permeable: no

Primary Target
UPA

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM for factor Xa

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following initial thaw, aliquot and refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.

Reconstitute at 1 mg/ml in 10 mM HCl. Dilute with physiological buffers just prior to use.

Other Notes

Bajaj, S.P., et al. 1992. Proc. Natl. Acad. Sci. USA89, 152.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable