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Merck

D-062

Supelco

21-Deoxycortisol solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C21H30O4
Número de CAS:
Peso molecular:
346.46
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C

InChI

1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1

InChI key

LCZBQMKVFQNSJR-UJPCIWJBSA-N

General description

A new calibration material suitable for LC/MS applications in clinical and diagnostic testing and endocrinology. 21-deoxycortisol, a steroid intermediate in the formation of cortisol, is measured in whole blood or serum by LC/MS for newborn screening of congenital adrenal hyperplasia (CAH) and other adrenal diseases.

Application

  • Steroid profiling for the diagnosis of congenital adrenal hyperplasia by microbore ultra-performance liquid chromatography-tandem mass spectrometry: This article emphasizes the significance of steroid profiling using advanced chromatography techniques to diagnose congenital adrenal hyperplasia, highlighting the role of 21-Deoxycortisol as a critical marker (Feng D et al., 2023).
  • Second-tier Testing for 21-Hydroxylase Deficiency in the Netherlands: A Newborn Screening Pilot Study: This study introduces a second-tier testing protocol involving 21-Deoxycortisol to enhance the screening process for congenital adrenal hyperplasia in newborns, demonstrating its utility in early and accurate diagnosis (Stroek K et al., 2021).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Related product

Referencia del producto
Descripción
Precios

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

K Müssig et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 114(4), 208-214 (2006-05-18)
Congenital adrenal hyperplasia results from 21-hydroxylase deficiency in more than ninety percent of cases. The classical form of 21-hydroxylase deficiency presents in the neonatal period with virilization or adrenal insufficiency, with or without concurrent salt wasting. We report on a
Diagnosing Cushing's syndrome.
A A Ismail et al.
Annals of clinical biochemistry, 35 ( Pt 2), 324-325 (1998-04-21)
A Milewicz et al.
Endokrynologia Polska, 44(2), 187-193 (1993-01-01)
The study was aimed at evaluation of usefulness of determination of blood serum 21-deoxycortisol concentration for the detection of heterozygous carriers of incomplete block of 21-hydroxylase synthesis leading to adrenal hyperplasia. An earlier observation of the authors that the determination
Simone Cristoni et al.
Rapid communications in mass spectrometry : RCM, 18(1), 77-82 (2003-12-23)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mainly caused by 21-hydroxylase deficit (21-OHD). Deletions or mutations of the CYP21 gene induce the impairment of glucocorticoid and mineralcorticoid synthesis. 17-Hydroxyprogesterone (17-OHP) is the hormonal marker in patients, but not
[21-Deoxycortisol].
Y Okatani
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 2, 444-447 (1995-03-01)

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