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D161802

Sigma-Aldrich

N,N′-Dimethylhydrazine dihydrochloride

98%

Sinónimos:

1,2-Dimethylhydrazine dihydrochloride, N,N′-Dimethylhydrazine (sym.) dihydrochloride

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About This Item

Fórmula lineal:
CH3NHNHCH3 · 2HCl
Número de CAS:
306-37-6
Peso molecular:
133.02
Beilstein/REAXYS Number:
3905684
EC Number:
206-183-5
MDL number:
MFCD00012522
UNSPSC Code:
12352100
PubChem Substance ID:
24893498
NACRES:
NA.22

assay

98%

form

crystals

mp

167-169 °C (dec.) (lit.)

SMILES string

Cl[H].Cl[H].CNNC

InChI

1S/C2H8N2.2ClH/c1-3-4-2;;/h3-4H,1-2H3;2*1H

InChI key

WLDRFJDGKMTPPV-UHFFFAOYSA-N

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Biochem/physiol Actions

Induces colon cancer in rats and mice.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Regulatory toxicology and pharmacology : RTP, 112, 104578-104578 (2020-01-15)
Genotoxicity occurring at the target organs of carcinogenesis is important for understanding the mechanisms of chemical carcinogenicity and also for setting of threshold estimation. In vivo gene mutations have been evaluated by transgenic animal models in which any organ can
Reema Narayan et al.
Carbohydrate polymers, 261, 117893-117893 (2021-03-27)
Glycosylated pH-sensitive mesoporous silica nanoparticles (MSNs) of capecitabine (CAP) were developed for targeting colorectal cancer. The MSNs possessed an average pore diameter of 8.12 ± 0.43 nm, pore volume of 0.73 ± 0.21 cm3/g, and particle size of 245.24 ±
Vijay L Kumar et al.
Drug development research, 80(8), 1089-1097 (2019-09-01)
Anti-inflammatory drugs are well known to reduce the risk of colon cancer and prophylactic use of such agents is gaining acceptance as a cancer prevention therapy. As artesunate, an antimalarial drug, has been shown to exhibit chemopreventive properties, the present
Preety Ghanghas et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 78, 239-247 (2016-02-24)
Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive agents against a variety of cancers owing to their capability in blocking the tumor development by cellular proliferation and by promoting apoptosis. Inflammation is principal cause of colon carcinogenesis. A missing
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Bioorganic & medicinal chemistry, 27(6), 1034-1042 (2019-02-19)
Selective proteinase inhibitors have demonstrated utility in the investigation of cartilage degeneration mechanisms and may have clinical use in the management of osteoarthritis. The cysteine protease cathepsin K (CatK) is an attractive target for arthritis therapy. Here we report the
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