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C85778

Sigma-Aldrich

o-Cresolphthalein

Indicator grade, powder

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About This Item

Fórmula empírica (notación de Hill):
C22H18O4
Número de CAS:
596-27-0
Peso molecular:
346.38
Beilstein/REAXYS Number:
310554
EC Number:
209-881-8
MDL number:
MFCD00005912
UNSPSC Code:
12171500
PubChem Substance ID:
24893078
NACRES:
NA.47

product name

o-Cresolphthalein, indicator grade

grade

indicator grade

form

powder

technique(s)

titration: suitable

color

beige

pH

8.2-9.8, colorless to red

mp

219-221 °C (lit.)

λmax

381 nm (2nd)
566 nm

ε (extinction coefficient)

≥10000 at 294-300 nm
≥39000 at 564-570 nm
≥5000 at 378-384 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cc1cc(ccc1O)C2(OC(=O)c3ccccc23)c4ccc(O)c(C)c4

InChI

1S/C22H18O4/c1-13-11-15(7-9-19(13)23)22(16-8-10-20(24)14(2)12-16)18-6-4-3-5-17(18)21(25)26-22/h3-12,23-24H,1-2H3

Inchi Key

CPBJMKMKNCRKQB-UHFFFAOYSA-N

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Application

O-Cresolphthalein has been used as a component in calcifying media for calcification assay.

Biochem/physiol Actions

o-Cresolphthalein is a reversible pH indicator. The kinetics of the reverse pathway (red-purple to colorless) is slow, thereby making it an appropriate molecule to check flow patterns in ducts with corrugated walls. It is also used for the colorimetric determination of calcium content via the o-cresolphthalein complexone method. Binding of calcium to o-cresolphthalein, in the presence of alkaline conditions (pH 10-12), results in the formation of a red complex with an absorbance at 570-575nm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Natalia Campos-Obando et al.
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Hyperphosphatemia has been associated with increased mortality in chronic kidney disease but the nature of such a relation in the general population is unclear. To investigate the association between phosphate (P) levels and all-cause and cause-specific mortality, we assessed two
Hyunseok Peter Kang et al.
Clinical chemistry, 50(4), 741-746 (2004-02-14)
Gadolinium formulations, which are administered as contrast agents in magnetic resonance imaging examinations, interfere with colorimetric serum calcium determinations. We performed an in vitro study to determine the extent to which three gadolinium formulations-gadodiamide (Omniscan), gadopentetate dimeglumine (Magnevist), and gadoversetamide
Jin-Hyun Kim et al.
PloS one, 14(4), e0215244-e0215244 (2019-04-17)
In the stratum corneum, the intercellular junction made up of cadherin proteins provides the structural integrity of the framework. Ca2+ ions are known to play a key role in maintaining this junction. In this study, we hypothesized that Ca2+ chelation
Diabetic vascular calcification mediated by the collagen receptor discoidin domain receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-related transcription factor 2 signaling axis
Lino M, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(8), 1878-1889 (2018)
J E Van Nuwenborg et al.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 35(4), 297-300 (1997-04-01)
We evaluated bias and inaccuracy of four frequently used routine test systems for serum total calcium, using a candidate reference method based on ion chromatography. The mean biases and 95% confidence intervals that we observed were 0.0 +/- 0.59% for
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