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C4790

Sigma-Aldrich

Carbenoxolone disodium salt

≥98%

Sinónimos:

3β-Hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate

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About This Item

Fórmula lineal:
C34H48O7Na2
Número de CAS:
7421-40-1
Peso molecular:
614.72
EC Number:
231-044-0
MDL number:
MFCD00079043
UNSPSC Code:
12352108
PubChem Substance ID:
57654021
NACRES:
NA.22

Quality Level

100

assay

≥98%

form

powder

storage temp.

2-8°C

SMILES string

[Na].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)[C@]4([H])[C@@]5(C)CC[C@H](OC(=O)CCC(O)=O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

1S/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23?,24-,27+,30+,31?,32-,33+,34+;;/m0../s1

InChI key

BQENDLAVTKRQMS-FDPMUVMVSA-L

General description

Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Promotion of nasal absorption of insulin by glycyrrhetinic acid derivatives. I.
Mishima M, et al.
Journal of Pharmacobio-Dynamics, 12(1), 31-36 (1989)
Seo-Yeon Yoon et al.
The journal of pain : official journal of the American Pain Society, 14(2), 205-214 (2013-02-05)
Spinal glial cells contribute to the development of many types of inflammatory and neuropathic pain. Here the contribution of spinal astrocytes and astrocyte gap junctions to oxaliplatin-induced mechanical hypersensitivity was explored. The expression of glial fibrillary acidic protein (GFAP) in
R A Warwick et al.
European journal of pain (London, England), 17(4), 571-580 (2012-10-16)
Chemotherapy-induced peripheral neuropathy is a serious side effect in cancer treatment, a major manifestation being neuropathic pain that can be debilitating and can reduce the quality of life of the patient. Oxaliplatin and taxol are common anti-cancer drugs that induce
Jung-Sub Park et al.
Current biology : CB, 27(17), 2623-2629 (2017-08-22)
Topological distributions of individual cellular clocks have not been demonstrated in peripheral organs. The cochlea displays circadian patterns of core clock gene expression [1, 2]. PER2 protein is expressed in the hair cells and spiral ganglion neurons of the cochlea
Jeremy W Chopek et al.
Cell reports, 25(1), 146-156 (2018-10-04)
Layering of neural circuits facilitates the separation of neurons with high spatial sensitivity from those that play integrative temporal roles. Although anatomical layers are readily identifiable in the brain, layering is not structurally obvious in the spinal cord. But computational
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