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607851

Sigma-Aldrich

L-Glutamic acid-13C5,15N

98 atom % 15N, 98 atom % 13C, 95% (CP)

Sinónimos:

(S)-2-Aminopentanedioic acid-13C5,15N, 13C and 15N Labeled L-glutamic acid, Glu-13C5,15N

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About This Item

Fórmula lineal:
HO213C(13CH2)213CH(15NH2)13CO2H
Número de CAS:
202468-31-3
Peso molecular:
153.09
MDL number:
MFCD00144596
UNSPSC Code:
12352209
PubChem Substance ID:
24881981
NACRES:
NA.12

isotopic purity

98 atom % 13C
98 atom % 15N

assay

95% (CP)

form

solid

optical activity

[α]25/D +31.0°, c = 2 in 5 M HCl

technique(s)

bio NMR: suitable

mp

205 °C (dec.) (lit.)

mass shift

M+6

SMILES string

[15NH2][13C@@H]([13CH2][13CH2][13C](O)=O)[13C](O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1

InChI key

WHUUTDBJXJRKMK-UFLWJPECSA-N

General description

Glutamic acid is an amino acid with an acidic side group. It works as a proton donor. Decarboxylation of glutamic acid results in the formation of GABA (γ aminobutyric acid), a potent neurotransmitter. Isotope labeled amino acids are required for the production of isotopically labeled proteins.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

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Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kishore K Mahalingan et al.
Nature structural & molecular biology, 27(9), 802-813 (2020-08-05)
Glutamylation, introduced by tubulin tyrosine ligase-like (TTLL) enzymes, is the most abundant modification of brain tubulin. Essential effector proteins read the tubulin glutamylation pattern, and its misregulation causes neurodegeneration. TTLL glutamylases post-translationally add glutamates to internal glutamates in tubulin carboxy-terminal
Fumihiro Eto et al.
Scientific reports, 10(1), 7435-7435 (2020-05-06)
The brain consists of various areas with anatomical features. Neurons communicate with one another via excitatory or inhibitory synaptic transmission. Altered abundance of neurotransmitters, including glutamate and gamma-aminobutyric acid (GABA), in specific brain regions is closely involved in severe neurological
Harvey RA, et al.
Biochemistry (Lippincott's illustrated reviews) (2011)
Incorporation of radioactive amino acids into proteins of the microsome fraction of guinea-pig liver in a cell-free system.
SIMKIN JL and WORK TS
The Biochemical Journal, 67, 617-624 (1957)
Isotope labeling for solution and solid-state NMR spectroscopy of membrane proteins.
Verardi R, et al.
Advances in Experimental Medicine and Biology, 992, 35-62 (2012)
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