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  • Designer dyes: 'biomimetic' ligands for the purification of pharmaceutical proteins by affinity chromatography.

Designer dyes: 'biomimetic' ligands for the purification of pharmaceutical proteins by affinity chromatography.

Trends in biotechnology (1992-12-01)
C R Lowe, S J Burton, N P Burton, W K Alderton, J M Pitts, J A Thomas
ABSTRACT

Affinity chromatography has been extensively refined over the past few years to meet the more stringent criteria being placed on recombinant proteins as therapeutic products. New developments in the design of selective and stable ligands for affinity chromatography are establishing the technique as a routine tool in process-scale protein purification. Exploitation of sophisticated molecular modelling techniques in conjunction with binding and crystallographic studies has permitted the design of new, highly selective 'biomimetic' ligands for the target proteins.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Mimetic Yellow 1 PIKSI Column, suspension
Sigma-Aldrich
Mimetic Blue 2 PIKSI Column, suspension
Sigma-Aldrich
Mimetic Green 1 Ligand Affinity Adsorbent, suspension
Sigma-Aldrich
Mimetic Orange 3 Ligand Affinity Adsorbent, suspension
Sigma-Aldrich
Mimetic Yellow 2 PIKSI Column, suspension
Sigma-Aldrich
Mimetic Blue AP Ligand Affinity Adsorbent, suspension
Sigma-Aldrich
Mimetic Orange 3 PIKSI Column, suspension
Sigma-Aldrich
Mimetic Blue AP PIKSI column, suspension
Sigma-Aldrich
Mimetic Green 1 PIKSI Column, suspension
Sigma-Aldrich
Mimetic Blue SA PIKSI Column, suspension
Sigma-Aldrich
Mimetic Orange 1 PIKSI Column, suspension
Sigma-Aldrich
Mimetic Red 2 PIKSI column, suspension
Sigma-Aldrich
Mimetic Red 3 Ligand Affinity Adsorbent, suspension
Sigma-Aldrich
Mimetic Orange 1 Ligand Affinity Adsorbent, suspension
Sigma-Aldrich
Mimetic Red 2 Ligand Affinity Adsorbent, suspension