G1639

D-(+)-Galactosamine hydrochloride

BioReagent, suitable for cell culture

• Synonym(s): 2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₃NO₅ · HCl
• CAS Number: 1772-03-8
• Molecular Weight: 215.63
• Beilstein: 3697825
• EC Number: 217-198-1
• MDL number: MFCD00135830
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895072
• NACRES: NA.75

Properties

• biological source: fish cartilage (shark)
• product line: BioReagent
• Assay: ≥99%
• technique(s): cell culture | mammalian: suitable
• impurities: Glucosamine, essentially free
• solubility: water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
• InChI: 1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
• InChI key: CBOJBBMQJBVCMW-NQZVPSPJSA-N

Description

Application

D-(+)-Galactosamine hydrochloride has been used to:

• induce livery injury
• inflammatory liver injury
• acute liver failure (ALF) in mice

Biochem/physiol Actions

Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves