E6627

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt

≥99% (capillary GC)

• Linear Formula: CH₃(CH₂CH=CH)₅(CH₂)₃CO₂Na
• CAS Number: 73167-03-0
• Molecular Weight: 324.43
• MDL number: MFCD00079184
• UNSPSC Code: 12352211
• PubChem Substance ID: 24894631
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥99% (capillary GC)
• form: film or powder
• color: white to off-white
• solubility: methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
• InChI: 1S/C20H30O2.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;;/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22);;/b4-3-,7-6-,10-9-,13-12-,16-15-;;
• InChI key: TVEGTERCKGGVCJ-LIJGWLRISA-N
• Gene Information: human ... ALOX5(240) ; mouse ... ALOX5(11689) ; rat ... ALOX5(25290)

Description

General description

Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.

Application

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:

• to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
• to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
• to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice

Biochem/physiol Actions

Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.

5-Lipoxygenase inhibitor; reduces thromboxane A2 production.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves