A3286

N-Acetyl-D-glucosamine

BioReagent, suitable for cell culture

• Synonym(s): 2-Acetamido-2-deoxy-D-glucose, D-GlcNAc
• Empirical Formula (Hill Notation): C₈H₁₅NO₆
• CAS Number: 7512-17-6
• Molecular Weight: 221.21
• Beilstein: 1727589
• EC Number: 231-368-2
• MDL number: MFCD00061615
• UNSPSC Code: 12352201
• PubChem Substance ID: 24890757
• NACRES: NA.75

Properties

• product line: BioReagent
• Assay: ≥95% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 211 °C (dec.) (lit.)
• storage temp.: −20°C
• SMILES string: CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
• InChI: 1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
• InChI key: OVRNDRQMDRJTHS-RTRLPJTCSA-N

Description

General description

N-Acetylglucosamine (GlcNAc), a derivative of glucose is a monosaccharide. It is a white powder and is mildly sweet. It melts at 221°C. GlcNAc is 25% soluble in water. It is present in bromelain, ricin agglutinin and abrus agglutinin, in plants. In humans, it is present in tissue plasminogen activator, growth factors and hormones.

Application

N-Acetyl-D-glucosamine addition has been used:

• as a substrate to develop dot-blots
• as a substrate to reveal alkaline phosphatase in the immunohistochemical analysis
• to detect specific immune complexes in western blot analysis

Biochem/physiol Actions

N-Acetylglucosamine (GlcNAc) oligomer may have the ability to initiate factors for canine polymorphonuclear cells (PMN) in vivo. It possesses wound healing and chemotactic activity. GlcNAc and its derivatives are usually employed in preparing dietary supplements and also used in therapeutic development.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves