C80105

Chrysin

≥96.5% purity, powder

• Synonym(s): 5,7-Dihydroxyflavone
• Empirical Formula (Hill Notation): C₁₅H₁₀O₄
• CAS Number: 480-40-0
• Molecular Weight: 254.24
• Beilstein: 233276
• EC Number: 207-549-7
• MDL number: MFCD00006834
• UNSPSC Code: 12171500
• PubChem Substance ID: 24893009
• NACRES: NA.47

Properties

• product name: Chrysin, ≥96.5%
• Assay: ≥96.5%
• form: powder
• color: beige
• mp: 284-286 °C (lit.)
• solubility: 0.1 M NaOH: 0.008 g/L
• λmax: 348 nm
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: room temp
• SMILES string: Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
• InChI key: RTIXKCRFFJGDFG-UHFFFAOYSA-N
• Gene Information: human ... CDC2(983) , CDK5(1020) , CDK6(1021) , CYP19A1(1588) , CYP1A2(1544) , GSK3A(2931) ; mouse ... Hexa(15211) , Ptgs2(19225) ; rat ... Gabra2(29706)

Description

Application

• Chrysin has been used to study the effect of bioflavonoids on the inhibition of ATP synthase in Escherichia coli.
• It has been used to study the effect of Chrysin on eIF4E (eukaryotic translation initiation factor 4E) expression in AGS cell (human gastric carcinoma cell) line.
• It has been used to study the effect of chrysin on human ovarian cancer cells.

Biochem/physiol Actions

Chrysin is a flavonoid and an analog of apigenin. It inhibits aromatase and also suppresses human immunodeficiency virus (HIV) activation in models with latent infection. Chrysin exhibits anti-inflammatory and anti-oxidant effects. This molecule induces apoptosis in various cells, thereby exhibiting cancer chemopreventive activity. Chrysin can modulate the activity of GABAA (Type-A γ-aminobutyric acid) and GABAC receptors, it downregulates expression of PCNA (proliferating cell nuclear antigen), reduces activity of CDK2 (cyclin-dependent kinase 2) and CDK4 and induces p38-MAPK (mitogen-activated protein kinase) activation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves