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471526

Sigma-Aldrich

1-Dimethylamino-2-propanol

≥99%

Synonym(s):

N,N-Dimethylisopropanolamine

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About This Item

Linear Formula:
CH3CH(OH)CH2N(CH3)2
CAS Number:
108-16-7
Molecular Weight:
103.16
Beilstein:
1209244
EC Number:
203-556-4
MDL number:
MFCD00004532
UNSPSC Code:
12352100
PubChem Substance ID:
24870740
NACRES:
NA.22

vapor density

3.6 (vs air)

vapor pressure

8 mmHg ( 20 °C)

Assay

≥99%

refractive index

n20/D 1.419 (lit.)

bp

121-127 °C (lit.)

density

0.837 g/mL at 25 °C (lit.)

SMILES string

CC(O)CN(C)C

InChI

1S/C5H13NO/c1-5(7)4-6(2)3/h5,7H,4H2,1-3H3

InChI key

NCXUNZWLEYGQAH-UHFFFAOYSA-N

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General description

1-Dimethylamino-2-propanol (1DMA2P, DMAPH), a tertiary amine, is a dimethylamino-alcohol having high boiling point. It is a potent protector against mechlorethamine cytotoxicity and inhibitor of choline uptake. Kinetics of homogeneous reaction of carbon dioxide (CO2) with 1-dimethylamino-2-propanol in water has been investigated using stopped-flow technique.

Application

1-Dimethylamino-2-propanol solution may be used in the synthesis of the following:
  • novel unsymmetrical 2,3,9,10,16,17,23-heptakis(alkoxyl)-24-mono(dimethylaminoalkoxyl)phthalocyanine compounds
  • homoleptic nickel(II) aminoalkoxide
  • Adduct with cobalt(II) 2,4-pentanedionate (acac)

Signal Word

Danger

Hazard Statements

H226,H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

78.8 °F - DIN 51755 Part 1

Flash Point(C)

26 °C - DIN 51755 Part 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S A Naujokaitis et al.
Journal of pharmaceutical sciences, 73(1), 34-39 (1984-01-01)
The structure-activity relationships of 2-dimethylaminoethanol and its analogues as protectors against mechlorethamine cytotoxicity and as inhibitors of choline uptake were evaluated. Of a series of inhibitors and protectors, 2-dimethylaminoethanol was the most potent inhibitor of choline uptake and the most
Synthesis and molecular structures of cobalt (II) ?-diketonate complexes as new MOCVD precursors for cobalt oxide films.
Pasko S, et al.
Polyhedron, 23(5), 735-741 (2004)
Soluble Ni II alkoxides based on dimethylaminoisopropoxide ligands: molecular structure of [Li (Pr i OH) Ni (η 2-OR)2 Cl]2 and of cis-NiCl2 (ROH)2 (R= CHMeCH2NMe2).
Hubert-Pfalzgraf LG, et al.
Polyhedron, 16(24), 4197-4203 (1997)
Kinetics of carbon dioxide (CO 2) with ethylenediamine, 3-amino-1-propanol in methanol and ethanol, and with 1-dimethylamino-2-propanol and 3-dimethylamino-1-propanol in water using stopped-flow technique
Kadiwala S, et al.
Chemical Engineering Journal, 179, 262-271 (2012)
Zhaopin Bai et al.
Inorganic chemistry, 49(19), 9005-9011 (2010-09-04)
A new pathway by means of transetherification has been developed to synthesize novel unsymmetrical 2,3,9,10,16,17,23-heptakis(alkoxyl)-24-mono(dimethylaminoalkoxyl)phthalocyanine compounds. Cyclic tetramerization of 4,5-di(alkoxyl)phthalonitrile in refluxing dimethylamino-alcohol with high boiling point such as dimethylaminoethanol (DMAE) and 1-dimethylamino-2-propanol in the presence of lithium and pyrazino[2,3-f][1,10]phenanthroline-2,3-dicarbonitrile
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