- Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21-1.
Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21-1.
Cancer medicine (2017-10-02)
Takayuki Kawai, Kentaro Yasuchika, Takamichi Ishii, Hokahiro Katayama, Elena Yukie Yoshitoshi, Satoshi Ogiso, Takahito Minami, Yuya Miyauchi, Hidenobu Kojima, Ryoya Yamaoka, Sadahiko Kita, Katsutaro Yasuda, Naoya Sasaki, Ken Fukumitsu, Etsuro Hatano, Shinji Uemoto
PMID28965351
ABSTRACT
The current lack of an easily measurable surrogate marker of cancer stem cells (CSCs) prevents the clinical application of CSCs for hepatocellular carcinoma (HCC). We previously reported that keratin 19 (K19) is a novel HCC-CSC marker associated with transforming growth factor beta (TGFβ)/Smad signaling, and that K19
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