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  • Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

Bioorganic & medicinal chemistry letters (1999-01-01)
R T Lum, M G Nelson, A Joly, A G Horsma, G Lee, S M Meyer, M M Wick, S R Schow
PMID9871656
ABSTRACT

Potent inhibitors of the 20S proteasome that contain a novel indanone head group coupled to di and tripeptides are described. These compounds are the first proteasome inhibitors have demonstrated high selectivity for the chymotrypsin-like activity of the 20S proteasome.