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  • CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Nature neuroscience (2013-05-28)
Elizabeth M Bradshaw, Lori B Chibnik, Brendan T Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C Morris, Denis A Evans, Keith Johnson, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager
PMID23708142
ABSTRACT

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

MATERIALS
Product Number
Brand
Product Description
09184
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~100,000
31417
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 5,000
31392
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31424
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 410,000
31398
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31430
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Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
31419
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Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 25,000
31420
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Dextran from Leuconostoc mesenteroides, for GPC, analytical standard, Mw 50,000
31416
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Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000
31418
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Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 12,000
31394
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Dextran, enzymatic synth.
31388
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Dextran from Leuconostoc spp., Mr ~6,000
00271
Supelco
Dextran, analytical standard, for GPC, 25,000
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Dextran, analytical standard, for GPC, 80,000
00896
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Dextran, analytical standard, for GPC, 670,000
00270
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Dextran, analytical standard, for GPC, 12,000
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Dextran from Leuconostoc spp., Mr 15,000-25,000
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Dextran, analytical standard, for GPC, 50,000
00268
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Dextran, analytical standard, for GPC, 1,000
D8802
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Dextran solution from Leuconostoc mesenteroides, 20 % (w/w) (Autoclaved)
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Dextran from Leuconostoc mesenteroides, average mol wt 150,000
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