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  • Complex N-heterocycle synthesis via iron-catalyzed, direct C-H bond amination.

Complex N-heterocycle synthesis via iron-catalyzed, direct C-H bond amination.

Science (New York, N.Y.) (2013-05-04)
Elisabeth T Hennessy, Theodore A Betley
ABSTRACT

The manipulation of traditionally unreactive functional groups is of paramount importance in modern chemical synthesis. We have developed an iron-dipyrrinato catalyst that leverages the reactivity of iron-borne metal-ligand multiple bonds to promote the direct amination of aliphatic C-H bonds. Exposure of organic azides to the iron dipyrrinato catalyst furnishes saturated, cyclic amine products (N-heterocycles) bearing complex core-substitution patterns. This study highlights the development of C-H bond functionalization chemistry for the formation of saturated, cyclic amine products and should find broad application in the context of both pharmaceuticals and natural product synthesis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Piperidine, puriss. p.a., ≥99.0% (GC/T)
Sigma-Aldrich
Piperidine, ≥99.5%, purified by redistillation
Sigma-Aldrich
Piperidine, ReagentPlus®, 99%
Sigma-Aldrich
Piperidine, biotech. grade, ≥99.5%
Sigma-Aldrich
Azetidine, 98%
Sigma-Aldrich
Piperidine solution, suitable for peptide synthesis, 20% in DMF