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M6552

Sigma-Aldrich

Monoclonal Anti-Matrix Metalloproteinase-3 antibody produced in mouse

clone SL-1 IIIC4, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-MMP-3

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About This Item

MDL number:
MFCD01094317
UNSPSC Code:
12352203

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

SL-1 IIIC4, monoclonal

form

buffered aqueous solution

mol wt

antigen ~48 kDa (active form)
antigen ~57 kDa (latent form)

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 using heat/pressure cooker pre-treatment
immunohistochemistry (frozen sections): 1:50-1:100
immunoprecipitation (IP): 10 using protein lysate (μL/mg)
indirect immunofluorescence: 4-5 μg/mL
western blot: 1:200-1:400 using conditioned medium from PMA-treated HT-1080 cells or bladder, breast, or ovarian carcinoma

isotype

IgG1

UniProt accession no.

P08254

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... MMP3(4314)

Immunogen

APMA-activated human matrix metalloproteinase-3 (stromelysin-1).

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Physical form

Solution in 10 mM phosphate buffered saline and 0.2% bovine serum albumin, pH 7.4, containing 0.1% sodium azide.

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Storage Class Code

12 - Non Combustible Liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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W Brian Saunders et al.
Journal of cell science, 118(Pt 10), 2325-2340 (2005-05-05)
Previous work has shown that endothelial cell (EC)-derived matrix metalloproteinases (MMPs) regulate regression of capillary tubes in vitro in a plasmin- and MMP-1 dependent manner. Here we report that a number of serine proteases can activate MMP-1 and cause capillary
Toru Ishibashi et al.
International immunopharmacology, 21(2), 468-473 (2014-06-15)
The aim of this study was to demonstrate the safety and efficacy of H2-saline infusion for treatment of rheumatoid arthritis (RA). We conducted a randomized, double-blind, placebo-controlled investigation of the infusion of 1 ppm H2-dissolved saline (H2-saline) in 24 RA
Thangarajan Rajkumar et al.
BMC cancer, 11, 80-80 (2011-02-23)
Cervical cancer is the most common cancer among Indian women. This cancer has well defined pre-cancerous stages and evolves over 10-15 years or more. This study was undertaken to identify differentially expressed genes between normal, dysplastic and invasive cervical cancer.
Brenda J Tripathi et al.
Experimental eye research, 78(3), 653-660 (2004-04-27)
We investigated the mRNA and protein expression of fibronectin and stromelysin-1 (matrix metalloproteinase-3, MMP-3) by trabecular cells treated with growth factors present in primary and secondary aqueous humors. Serum-deprived trabecular cells were incubated for 48 hr or 7 days in
Chuan Ma et al.
PloS one, 9(9), e107544-e107544 (2014-09-17)
To examine the possible involvement and regulatory mechanisms of extracellular signal-regulated kinase (ERK) pathway in the temporomandibular joint (TMJ) of rats subjected to chronic sleep deprivation (CSD). Rats were subjected to CSD using the modified multiple platform method (MMPM). The
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