C7017

Choline chloride

≥99%

• Synonym(s): (2-Hydroxyethyl)trimethylammonium chloride
• Linear Formula: (CH₃)₃N(Cl)CH₂CH₂OH
• CAS Number: 67-48-1
• Molecular Weight: 139.62
• Beilstein: 3563126
• EC Number: 200-655-4
• MDL number: MFCD00011721
• UNSPSC Code: 50501514
• PubChem Substance ID: 57654039
• NACRES: NA.25

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ≥99%
• form: powder
• color: white
• mp: 302-305 °C (dec.) (lit.)
• lipid type: phospholipids
• SMILES string: [Cl-].C[N+](C)(C)CCO
• InChI: 1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
• InChI key: SGMZJAMFUVOLNK-UHFFFAOYSA-M

Description

General description

Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver.[1] It maintains cell structural integrity and cell signalling.[2] Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.[3]

Application

Choline chloride has been used:

• in choline release assay[4]
• as an endogenous agonist of sigma-1 receptors (Sig-1Rs)[5]
• as a standard to analyse interrelationships between methionine and choline metabolism[6]

Biochem/physiol Actions

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

Substrates

Choline acetyltransferase substrate

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves