NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Synonyms:
NEDD4-2, NEDD4.2, RSP5, hNEDD4-2
Species:
Human NEDD4L (23327), Mouse Nedd4l (83814), Rat Nedd4l (291553), sheep NEDD4L (101122748), Zebrafish nedd4l (559634), domestic guinea pig Nedd4l (100301562), domestic cat NEDD4L (101088369), Horse NEDD4L (100054395), Domestic Rabbit NEDD4L (100353099), cow NEDD4L (510003) ...More
UniProtKB ID:
Gene ID:
- Human(23327) Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
- Mouse(83814) neural precursor cell expressed, developmentally down-regulated gene 4-like
- Rat(291553) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- sheep(101122748) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- Zebrafish(559634) neural precursor cell expressed, developmentally down-regulated 4-like
- domestic guinea pig(100301562) neural precursor cell expressed, developmentally down-regulated gene 4-like
- domestic cat(101088369) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- Horse(100054395) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- Domestic Rabbit(100353099) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- cow(510003) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- dog(476189) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- naked mole-rat(101715398) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
- chicken(374119) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-NEDD4L antibody produced in mouse, clone 1D2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-NEDD4L Antibody, clone 3W9J2, Rabbit Monoclonal, ,
Species Reactivity
human
Application
western blot
Anti-NEDD4L antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-NEDD4L antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Phospho-NEDD4L-S448 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot