Mammalian cell cultures are widely used as the workhorse platform in the production of biological products such as antibodies or other therapeutic proteins. Deviations of critical process parameters (CPP) in upstream operations can directly lead to physicochemical and biological heterogeneities in the biological expression system and associated critical quality attributes (CQA) in therapeutic products. Hence, Process Analytical Technologies (PAT) represent an enabler to the Quality by Design (QbD) paradigm to generate adaptive processes that can maintain productivity and reduce product quality deviations through the implementation of process monitoring and control sensors.
In this webinar, you will receive:
- An introduction to Raman for bioprocess monitoring
- An overview of PAT and real-time monitoring benefits
- Practical case studies and applications for PAT
- A live demo and overview of our Raman PAT Platform - ProCellics™ Raman Analyzer with Bio4C™ PAT Raman Software
Speakers
Kevin Grollier
Merck
PAT Implementation & Support Engineer
Kevin Grollier graduated from the Lyon Pharmaceutical Industry Institute (IPIL), with an M.S. in pharmaceutical production specializing in biotechnology. This diploma was reinforced by training at the management school of Lyon. Within our company, he is a PAT Implementation and support engineer in charge of implementing Raman projects at customer sites, training ProCellics™ Raman Analyzer with Bio4C™ PAT Raman software users, and providing customers with technical support on hardware, software, and data analysis topics. Before joining our company, he worked at Merial (now BIAH) as a QA validation engineer where he had the opportunity to work on various items of the validation.
Pharma and biopharma manufacturing
- Viral Vector Upstream Processing
Duration:55min
Language:English
Session 1:presented October 21, 2021
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