Skip to Content
Merck
  • 3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

Polish journal of pharmacology and pharmacy (1980-03-01)
B Witczuk, R A Khaunina, G Kupryszewski
ABSTRACT

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one and 1.4-1.9-fold as effective as the racemate.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
R(+)-Baclofen hydrochloride, solid
Sigma-Aldrich
S(−)-Baclofen hydrochloride, ≥98% (HPLC), solid