- Catalytic hydroacylation as an approach to homoaldol products.
Catalytic hydroacylation as an approach to homoaldol products.
Organic letters (2011-11-09)
Stephen K Murphy, David A Petrone, Matthew M Coulter, Vy M Dong
PMID22060018
ABSTRACT
A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products in 50-98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.