N1905
Neurotrophin-3 human
recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)
Synonym(s):
HDNF, NTF3, NT-3
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About This Item
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biological source
human
Quality Level
recombinant
expressed in baculovirus infected Sf21 cells
Assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
1-40 ng/mL EC50
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... NTF3(4908)
General description
NTF3 (neurotrophin 3) is a neurotrophic factor belonging to the NGF (nerve growth factor) family. This protein is made up of 257 amino acids, with a prepro region of 138 amino acids and the mature sequence of 119 residues.
Application
Neurotrophin-3 human has been used in the magnetic sorting of oligodendrocyte progenitor cells.
Biochem/physiol Actions
Neurotrophin-3 (13.6 kDa or 27.2 kDa dimer) is a member of the neurotrophin family. It has identical amino acid sequence in human, mouse, and pig with full cross-reactivities. NT-3 is important in development and maintenance of neuronal populations and promotes differentiation of neural crest derived sensory and sympathetic neurons. It is critical for proprioceptive 1a afferent neurons, which relay information from peripheral muscle spindles to motoneurons, sending projections to spinocerebellar neurons. NT-3 is also critical in the superior cervical and nodose ganglia.
Physical form
Lyophilized from a 0.2 m filtered solution in phosphate buffered saline (PBS) containing 50 μg of bovine serum albumin (BSA) per 1 μg of cytokine.
Analysis Note
The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis
Louie E, et al.
Oncogene, 32(35), 4064-4064 (2013)
Defective glial maturation in vanishing white matter disease
Bugiani M, et al.
Journal of Neuropathology and Experimental Neurology, 70(1), 69-82 (2011)
Hong Zhai et al.
Biomedical materials (Bristol, England), 15(5), 055031-055031 (2020-06-20)
ADA16 peptide hydrogels have been broadly used in tissue engineering due to their good biocompatibility and nanofibrous structure mimicking the native extracellular matrix (ECM). However, the low mechanical strength often fails them as implantable scaffolds. To improve the mechanical stability
Callard, R., and Gearing, A.
The Cytokine Factsbook (1994)
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Molecular and cellular neurosciences, 88, 342-352 (2018-03-20)
CaBP1 is a Ca2+ binding protein that is widely expressed in neurons in the brain, retina, and cochlea. In heterologous expression systems, CaBP1 interacts with and regulates voltage-gated Cav Ca2+ channels but whether this is the case in neurons is
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