MTOX1094P24
MRP4 Knockout Caco-2 Cells
human cervix, Epithelial
Synonym(s):
MRP4 Knockout C2BBe1 Cells
About This Item
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product name
MRP4 Knockout Caco-2 Cells, one assay ready, 24 well plate
biological source
human colon
form
liquid
morphology
Epthelial
technique(s)
drug transporter assay: suitable
permeability assay: suitable
application(s)
ADME/TOX
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General description
The three week production lead time begins on the Monday following a purchase, in the third week the cells are shipped overnight for receipt on Tuesday or Wednesday. As a biologic product that′s shipped at room temperature the cells must be processed immediately upon receipt.
Application
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
Features and Benefits
- A functional knockout of the MRP4 gene eliminates the reliance on chemical inhibitors to determine if a compound is an MRP4 substrate
- The 24 well Transwell format enables the MRP4 knockout cells to be included in standard drug transporter protocols
- Human assay with no interference from animal inhibitors
- Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality
related product
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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