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860596P

Avanti

C18:1 Galactosyl(β) Ceramide (d18:1/18:1(9Z))

Avanti Research™ - A Croda Brand 860596P, powder

Synonym(s):

D-galactosyl-β-1,1′-N-oleoyl-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C42H79 NO8
CAS Number:
73039-25-5
Molecular Weight:
726.08
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (860596P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860596P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCC/C=C\CCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H](O)[C@H]1CO

General description

Galactosyl ceramide is a complex glycosphingolipid. It is a major component of the myelin sheath and contains a single galactose residue linked to ceramide.Galactosyl ceramide is present mainly on the surface of colonic epithelial cells, vaginal epithelium and primary mammary epithelial cells.

Biochem/physiol Actions

Galactosyl ceramide is essential for normal myelin function and stability. It blocks epithelial cell-human immunodeficiency virus 1 (HIV-1) virion binding.

Packaging

5 mL Amber Glass Screw Cap Vial (860596P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gangliosides in Health and Disease
Gangliosides in Health and Disease, 77(1), 306-318 (2018)
Pediatr Neurol
Pediatric Neurology, 77(1), 306-318 (2013)
K M Koshy et al.
Biophysical journal, 77(1), 306-318 (1999-07-02)
Divalent cations mediate a carbohydrate-carbohydrate association between the two major glycolipids, galactosylceramide (GalCer) and its sulfated form, cerebroside sulfate (CBS), of the myelin sheath. We have suggested that interaction between these glycolipids on apposed extracellular surfaces of myelin may be
S Moses Dennison et al.
Journal of virology, 88(16), 9406-9417 (2014-06-13)
Mucosal epithelial cell surface galactosylceramide (Galcer) has been postulated to be a receptor for HIV-1 envelope (Env) interactions with mucosal epithelial cells. Disruption of the HIV-1 Env interaction with such alternate receptors could be one strategy to prevent HIV-1 entry

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