Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

357375

Sigma-Aldrich

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267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

GF57762399

Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%

GF19578831

Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF15342016

Platinum, tube, 500mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%

GF26290313

Platinum, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%

GF22018553

Platinum, tube, 50mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF72566657

Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF06396532

Platinum, foil, 10mm disks, thickness 0.025mm, as rolled, 99.99+%

GF01692952

Platinum, wire reel, 0.05m, diameter 0.25mm, as drawn, 99.998%

GF41572414

Platinum, foil, 8mm disks, thickness 0.0075mm, as rolled, 99.95%

GF89210336

Platinum, foil, 4mm disks, thickness 0.025mm, as rolled, 99.95%

GF25102897

Platinum, foil, 0.5m coil, thickness 0.045mm, coil width .75mm, as rolled, 99.95%

GF88232542

Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.95%

GF87506208

Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%

GF74454824

Platinum, wire reel, 0.1m, diameter 0.006mm, wollaston, 99.9%

GF87499906

Platinum, foil, 6mm disks, thickness 0.004mm, as rolled, 99.95%

GF99566410

Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.99+%

GF85102837

Platinum, wire reel, 0.1m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%