Aciclovir-resistant herpes keratitis.

Aciclovir-resistant herpes keratitis.

Clinical & experimental ophthalmology (2010-05-08)

Keat Choong, Nathan J Walker, Andrew Jg Apel, Michael Whitby

PMID20447128

ABSTRACT

Herpes simplex virus (HSV) keratitis is a common cause of ocular morbidity. Resistance to aciclovir is probably under recognized. We describe three cases of aciclovir-resistant herpes simplex virus keratitis treated with systemic foscarnet and present a review of the pharmacological options available to manage this condition.

MATERIALS

Product Number

Brand

Product Description

A4669

Sigma-Aldrich

Acycloguanosine, ≥99% (HPLC), powder

1012065

USP

Acyclovir, United States Pharmacopeia (USP) Reference Standard

A0220000

Aciclovir, European Pharmacopoeia (EP) Reference Standard

PHR1254

Supelco

Acyclovir, Pharmaceutical Secondary Standard; Certified Reference Material