R3405

RP-107

≥98% (HPLC), solid

• Synonym(s): 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
• Empirical Formula (Hill Notation): C₁₆H₁₇N₃O
• CAS Number: 496864-15-4
• Molecular Weight: 267.33
• MDL number: MFCD04973541
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824024

Properties

• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
• InChI: 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• InChI key: PRIGRJPRGZCFAS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC₅₀ = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves