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GW20086F

Sigma-Aldrich

Anti-Human IgM antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Immunoglobulin M

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About This Item

MDL number:
MFCD00162468
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-20086F

technique(s)

western blot: suitable

UniProt accession no.

P01871

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IGHM(3507)

Immunogen

Human IgM native protein.

Application

Anti-Human IgM antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Ig μ chain C region is a protein encoded by the IGHM gene in humans and is expressed on the surface of T cells. It is associated with agammaglobulinemia-1. Immunoglobulin is expressed in epithelial cell and plays a role in growth and survival. IgG heavy chain is expressed in acute myeloid leukemia (AML). IgM derived from AML might be a novel AML-related molecule that is involved in leukemogenesis and AML progression. It may serve as a useful molecular marker for designing targeted therapy and monitoring minimal residual disease. Elevated levels of soluble IGM Ligand (sCD40L) were found in serum of patients with chronic spontaneous urticaria (CU).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jing Huang et al.
Cellular & molecular immunology, 11(1), 94-104 (2013-10-22)
Immunoglobulin (Ig), a characteristic marker of B cells, has been reported to be expressed in epithelial cells, with a suggested role in their growth and survival. We have previously reported that IgG heavy chain is expressed in acute myeloid leukemia
T Jasinska et al.
BioMed research international, 2013, 823798-823798 (2013-11-16)
Elevated levels of soluble CD40 Ligand (sCD40L) were found in serum but not in plasma of patients with chronic spontaneous urticaria (CU). What is important is that sCD40L has proinflammatory properties, and its elevated plasma level may indicate increased risk

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