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  • Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)
Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker
ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Platinum black, low bulk density, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum, gauze, 100 mesh, 99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Platinum, shot, ≤3 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum black, fuel cell grade, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis
Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, tube, 500mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%
Platinum, tube, 50mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%
Platinum, foil, 10mm disks, thickness 0.025mm, as rolled, 99.99+%
Platinum, wire reel, 0.05m, diameter 0.25mm, as drawn, 99.998%
Platinum, foil, 8mm disks, thickness 0.0075mm, as rolled, 99.95%
Platinum, foil, 4mm disks, thickness 0.025mm, as rolled, 99.95%
Platinum, foil, 0.5m coil, thickness 0.045mm, coil width .75mm, as rolled, 99.95%
Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.95%
Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%
Platinum, wire reel, 0.1m, diameter 0.006mm, wollaston, 99.9%
Platinum, foil, 6mm disks, thickness 0.004mm, as rolled, 99.95%
Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.99+%
Platinum, wire reel, 0.1m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .85mm, as rolled, 99.95%