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SML3504

Sigma-Aldrich

AM-2201

≥98% (HPLC)

Synonym(s):

1-(5-Fluoropentyl)-3-(1-naphthoyl) indole, AM 2201, JWH 2201, [1-(5-Fluoropentyl)-1H-indol-3-yl]-1-naphthalenylmethanone

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About This Item

Empirical Formula (Hill Notation):
C24H22FNO
CAS Number:
335161-24-5
Molecular Weight:
359.44
MDL number:
MFCD16620503
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule I

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

wet ice

storage temp.

-10 to -25°C

SMILES string

O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(C4=CC=CC=C43)CCCCCF

InChI

1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2

InChI key

ALQFAGFPQCBPED-UHFFFAOYSA-N

Biochem/physiol Actions

AM-2201 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 1.0nM at CB1 and 2.6nM at CB2. AM-2201 is more potent than phytocannabinoid Δ9-tetrahydrocannabinol.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H336

Hazard Classifications

STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stefan Kneisel et al.
Journal of mass spectrometry : JMS, 47(7), 825-835 (2012-07-14)
The analysis of synthetic cannabinoids in human matrices is of particular importance in the fields of forensic and clinical toxicology since cannabis users partly shift to the consumption of 'herbal mixtures' as a legal alternative to cannabis products in order
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites.
Xingxing Diao
Frontiers in Chemistry, 7, 109-109 (2019)
Jeremy Carlier et al.
The Journal of pharmacology and experimental therapeutics, 367(3), 543-550 (2018-09-30)
Novel synthetic cannabinoids are appearing in recreational drug markets worldwide. Pharmacological characterization of these new drugs is needed to inform clinicians, toxicologists, and policy makers who monitor public health. [1-(5-Fluoropentyl)-1H-indol-3-yl](1-naphthyl)methanone (AM-2201) is an abused synthetic cannabinoid that was initially created

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