63177

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

≥98.0% (HPLC)

• Synonym(s): 6-Maleimidocaproic acid N-succinimidyl ester, N-(ε-Maleimidocaproyloxy)succinimide, N-Succinimidyl 6-maleimidocaproate, EMCS
• Empirical Formula (Hill Notation): C₁₄H₁₆N₂O₆
• CAS Number: 55750-63-5
• Molecular Weight: 308.29
• Beilstein: 1499815
• MDL number: MFCD00043043
• UNSPSC Code: 12352106
• PubChem Substance ID: 329759804
• NACRES: NA.25

Properties

• Quality Level: 200
• Assay: ≥98.0% (HPLC)
• form: solid
• reaction suitability: reagent type: linker
• mp: 67-73 °C; 70-73 °C (lit.)
• functional group: NHS ester
• storage temp.: −20°C
• SMILES string: O=C(ON(C(CC1)=O)C1=O)CCCCCN2C(C=CC2=O)=O
• InChI: 1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2
• InChI key: VLARLSIGSPVYHX-UHFFFAOYSA-N

Description

Application

6-Maleimidohexanoic acid N-hydroxysuccinimide ester is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Reagent for cross-linking and immobilisation of proteins

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves