02487

Chloroform

analytical standard

• Synonym(s): Methylidyne trichloride, Trichloromethane
• Empirical Formula (Hill Notation): CHCl₃
• CAS Number: 67-66-3
• Molecular Weight: 119.38
• Beilstein: 1731042
• EC Number: 200-663-8
• MDL number: MFCD00000826
• UNSPSC Code: 12191502
• PubChem Substance ID: 329747448
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• vapor density: 4.1 (vs air)
• vapor pressure: 160 mmHg ( 20 °C)
• Assay: ≥99.9% (GC)
• shelf life: limited shelf life, expiry date on the label
• contains: ~0.003% amylene as stabilizer
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.444-1.447; n20/D 1.445 (lit.)
• bp: 60.5-61.5 °C (lit.)
• mp: −63 °C (lit.)
• density: 1.492 g/mL at 25 °C (lit.)
• application(s): agriculture; cleaning products; cosmetics; environmental; food and beverages; personal care
• format: neat
• SMILES string: ClC(Cl)Cl
• InChI: 1S/CHCl3/c2-1(3)4/h1H
• InChI key: HEDRZPFGACZZDS-UHFFFAOYSA-N

Description

General description

Chloroform is a colorless, volatile, liquid derivative of trichloromethane with an ether-like odor. It is a commonly used laboratory solvent. Presently, it is used in the industry as a solvent and in the production of the refrigerant freon. It is majorly used in production of chlorodifluoromethane, which is a refrigerant and fluoropolymer feedstock. It degrades in air to produce phosgene, dichloromethane, formyl chloride, CO, CO2 and hydrogen chloride. It can be orally consumed or inhaled, as it can be quickly absorbed, metabolized and eliminated by mammals.

Application

• Chloroform for organic synthesis: Chloroform is widely used in organic synthesis, providing a reliable solvent for the creation and purification of chemical compounds. It facilitates various reactions, including the integration of lipid analysis using advanced chromatographic techniques (Panczel et al., 2024).


• Chloroform as a catalyst in organic synthesis: Employed as a catalyst, chloroform enhances the catalytic efficiencies of various biochemical reactions, such as the activation methods in catalytic studies, aiding in the development of more efficient and sustainable chemical processes (Behera et al., 2024).

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• Precautionary Statements: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Target Organs: Central nervous system, Liver,Kidney
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): does not flash
• Flash Point(C): does not flash
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves