- An unconventional BST-2 function: down-regulation of transient protein expression.
An unconventional BST-2 function: down-regulation of transient protein expression.
Biochemical and biophysical research communications (2014-07-16)
Jaraspim Narkpuk, Asawin Wanitchang, Jarin Kramyu, Phanramphoei Namprachan Frantz, Anan Jongkaewwattana, Samaporn Teeravechyan
PMID25019996
ABSTRACT
While viral inhibition by tethering of budding virions to host cell membranes has been focused upon as one of the main functions of BST-2/tetherin, BST-2 is thought to possess other functions as well. Overexpression of BST-2 was found here to down-regulate transient protein expression. Removal of the N- and C-terminal regions of BST-2, previously described to be involved in signal transduction, reduced the impact of BST-2. These results suggest that BST-2-mediated signaling may play a role in regulating the levels of transiently expressed proteins, highlighting a new function for BST-2 that may also have implications for viral inhibition.