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  • Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)
George Psomas, Dimitris P Kessissoglou
ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%
Cobalt, foil, light tested, 50x50mm, thickness 0.05mm, as rolled, 99.99+%
Cobalt, foil, not light tested, 100x100mm, thickness 0.004mm, 99.9%
Cobalt, foil, not light tested, 25x25mm, thickness 0.007mm, 99.9%
Cobalt, foil, light tested, 25x25mm, thickness 0.0125mm, 99.9%
Cobalt, foil, not light tested, 150x150mm, thickness 0.01mm, 99.9%
Cobalt, foil, not light tested, 25x25mm, thickness 0.008mm, 99.9%
Cobalt, foil, not light tested, 150x150mm, thickness 0.025mm, 99.9%
Cobalt, foil, not light tested, 25x25mm, thickness 0.009mm, 99.9%
Cobalt, foil, not light tested, 100x100mm, thickness 0.006mm, 99.9%
Cobalt, foil, light tested, 25x25mm, thickness 0.01mm, 99.9%
Cobalt, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.9%
Cobalt, foil, not light tested, 100x100mm, thickness 0.005mm, 99.9%
Cobalt, foil, not light tested, 25x25mm, thickness 0.01mm, 99.9%
Cobalt, foil, not light tested, 100x100mm, thickness 0.009mm, 99.9%
Cobalt, wire reel, 0.05m, diameter 1.0mm, hard, 99.99+%
Cobalt, foil, not light tested, 25x25mm, thickness 0.0025mm, temporary acrylic support, 99.9%
Cobalt, foil, light tested, 50x50mm, thickness 0.015mm, 99.9%
Cobalt, microfoil, disks, 10mm, thinness 0.5μm, specific density 434μg/cm2, permanent mylar 3.5μm support, 99.9%
Cobalt, foil, not light tested, 100x100mm, thickness 0.0125mm, 99.9%
Cobalt, wire reel, 0.05m, diameter 2.0mm, hard, 99.99+%
Cobalt, foil, not light tested, 150x150mm, thickness 0.0125mm, 99.9%
Cobalt, foil, light tested, 50x50mm, thickness 0.0125mm, 99.9%
Cobalt, foil, not light tested, 50x50mm, thickness 0.0025mm, temporary acrylic support, 99.9%
Cobalt, foil, not light tested, 25x25mm, thickness 0.003mm, 99.9%
Cobalt, foil, not light tested, 50x50mm, thickness 0.002mm, temporary acrylic support, 99.9%
Cobalt, wire reel, 0.1m, diameter 0.125mm, hard, 99.99+%
Nickel, foil, 5m coil, thickness 0.025mm, annealed, 99%
Nickel, foil, 5m coil, thickness 0.05mm, annealed, 99%
Nickel, foil, 5m coil, thickness 0.05mm, coil width 2mm, annealed, 99%