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One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

Molecules (Basel, Switzerland) (2012-11-13)

Zhang-Gao Le, Zong-Bo Xie, Jian-Ping Xu

ABSTRACT

One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions in the presence of Na(2)CO(3), gave the corresponding 2-phenylimidazo[1,2-α]pyridines in excellent yields ranging from 72% to 89%.

MATERIALS

Product Number

Brand

Product Description

Supelco

Sodium carbonate, reference material for titrimetry, certified by BAM, >99.5%

Sigma-Aldrich

Acetophenone, puriss. p.a., ≥99.0% (GC)

Sigma-Aldrich

Sodium carbonate, BioUltra, anhydrous, ≥99.5% (calc. on dry substance, T)

Sigma-Aldrich

Sodium carbonate, BioXtra, ≥99.0%

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Acetophenone, ReagentPlus^®, 99%

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Acetophenone, ≥98%, FG

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Sodium carbonate, anhydrous, powder, 99.999% trace metals basis

Supelco

Acetophenone, analytical standard

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Sodium carbonate decahydrate, 99.999% trace metals basis

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Sodium carbonate decahydrate, puriss. p.a., ≥99.0% (T)

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Sodium carbonate monohydrate, puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, E500, 99.5-100.5% (ex dried subst.)

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Sodium carbonate, ACS reagent, anhydrous, ≥99.5%, powder or granules

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Sodium carbonate, ACS reagent (primary standard), anhydrous, 99.95-100.05% dry basis

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Sodium carbonate monohydrate, ACS reagent, ≥99.5%

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Sodium carbonate, powder, ≥99.5%, ACS reagent

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Sodium carbonate monohydrate, ReagentPlus^®, ≥99.5%

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Sodium carbonate, ReagentPlus^®, ≥99.5%

Supelco

Sodium carbonate concentrate, 0.1 M Na₂CO₃ in water, eluent concentrate for IC

Supelco

2-Aminopyridine, PESTANAL^®, analytical standard

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2-Aminopyridine, ≥99%

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2-Aminopyridine, 99%

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Sodium carbonate-¹²C, 99.9 atom % ¹²C

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2-Aminopyridine, purum, ≥98.0% (NT)

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Sodium carbonate concentrate, Na₂CO₃ 72 mM in water, IC eluent concentrate (20x) for Metrosep A Supp 7