- A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.
A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.
Biochimica et biophysica acta (2000-04-29)
K C Neal, A Pannuti, E R Smith, J C Lucchesi
PMID10786633
ABSTRACT
We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins.
MATERIALS
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KAT8 (2-467), GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution