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E3158

Sigma-Aldrich

Anti-ERG (171-185) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-ERG Isoform 5 of Transcriptional regulator ERG, Anti-Erg-3, Anti-p55

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W217409-SAMPLE-K
64.351 ₩
1 KG
91.350 ₩
9 KG
422.342 ₩
20 KG
718.316 ₩

64.351 ₩


Please contact Customer Service for Availability


Select a Size

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W217409-SAMPLE-K
64.351 ₩
1 KG
91.350 ₩
9 KG
422.342 ₩
20 KG
718.316 ₩

About This Item

UNSPSC Code:
12352203

64.351 ₩


Please contact Customer Service for Availability

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~54 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

Immunogen

synthetic peptide corresponding to amino acids 171-185 of human ERG

Application

Anti-ERG (171-185) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

ERG (ETS-related gene) is an oncogene encoding for a protein that is mutated in cancer. It belongs to the Ets family of transcription factors and is critically important for maintenance of hematopoietic stem cell population. Majority of human prostate cancers is caused due to overexpression of ERG.[1] ERG overexpression is found among intermediate and high-risk tumors.[2] ERG expression has potential to act as biomarkers and therapeutic targets for prostate tumors. It is also useful in inhibiting cell differentiation and activating cell growth.[3]

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Michael C Regan et al.
    Proceedings of the National Academy of Sciences of the United States of America, 110(33), 13374-13379 (2013-07-31)
    The Ets-Related Gene (ERG) belongs to the Ets family of transcription factors and is critically important for maintenance of the hematopoietic stem cell population. A chromosomal translocation observed in the majority of human prostate cancers leads to the aberrant overexpression
    Eliza M Raymundo et al.
    The Prostate, 74(11), 1079-1085 (2014-06-10)
    Filipinos with prostate cancer (CaP) are at increased risk of harboring advanced stages and lower survival rates compared to other Asians. This study aims to investigate prevalence of ETS-related gene (ERG) oncoprotein overexpression in Filipinos as surrogate of TMPRSS2-ERG gene
    Shyh-Han Tan et al.
    The Prostate, 74(1), 70-89 (2013-10-12)
    Gene fusion between TMPRSS2 promoter and the ERG proto-oncogene is a major genomic alteration found in over half of prostate cancers (CaP), which leads to aberrant androgen dependent ERG expression. Despite extensive analysis for the biological functions of ERG in
    Thomas M Schneider et al.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(8), 1174-1178 (2014-01-11)
    Intraductal carcinoma of the prostate is a growth pattern of prostatic adenocarcinoma that has not been well characterized from the molecular standpoint. It remains debatable whether intraductal carcinoma of the prostate represents colonization of benign glands by pre-existing conventional prostatic
    Miwa Tanaka et al.
    The Journal of clinical investigation, 124(7), 3061-3074 (2014-06-10)
    Ewing's sarcoma is a highly malignant bone tumor found in children and adolescents, and the origin of this malignancy is not well understood. Here, we introduced a Ewing's sarcoma-associated genetic fusion of the genes encoding the RNA-binding protein EWS and

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