A172
1-Aminocyclobutane-cis-1,3-dicarboxylic acid
Synonym(s):
1-Amino-cis-1,3-cyclobutanedicarboxylic acid, cis-ACDA
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About This Item
UNSPSC Code:
12352200
solubility
0.1 M NaOH: 12 mg/mL
0.1 M HCl: 14 mg/mL
H2O: 5.2 mg/mL
methanol: insoluble
Biochem/physiol Actions
Potent and selective NMDA receptor agonist
Other Notes
Note: Under IUPAC nomenclature, this compound is designated as trans
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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R D Allan et al.
Journal of medicinal chemistry, 33(10), 2905-2915 (1990-10-01)
We report the synthesis of a series of 3-carboxy-, 3-(carboxymethyl)-, 3-(omega-phosphonoalkyl)-1-aminocyclobutane-1-carboxylic acids for evaluation as agonists or antagonists of neurotransmission at excitatory amino acid receptors, particularly N-methyl-D-aspartic acid (NMDA) receptors. The compounds were evaluated as agonists on their ability to
Barbara Banelli et al.
Cell cycle (Georgetown, Tex.), 14(21), 3418-3429 (2015-11-15)
Notwithstanding current multimodal treatment, including surgery, radiotherapy and chemotherapy with temozolomide (TMZ), median survival of glioblastoma (GBM) patients is about 14 months, due to the rapid emergence of cell clones resistant to treatment. Therefore, understanding the mechanisms underlying chemoresistance is
Yuri Chikano et al.
Molecular cancer therapeutics, 14(2), 564-574 (2014-12-17)
The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer.
Xiujuan Shi et al.
Molecular medicine reports, 11(5), 3533-3538 (2015-01-13)
Spindle and kinetochore‑associated protein 1 (SKA1) is an important component of the human kinetochore, which plays a key role in mitosis. The resent study was designed to investigate the role of SKA1 in human glioblastoma. The results of the present
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