CR1
complement component (3b/4b) receptor 1 (Knops blood group)
Synonyms:
C3BR, C4BR, CD35, KN
Species:
Human CR1 (1378), dog CR1 (609328), domestic cat CR1 (101094393), Domestic Rabbit CR1 (100144334), naked mole-rat Cr1 (101704987)
UniProtKB ID:
Gene ID:
- Human(1378) Summary: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
- dog(609328) complement component (3b/4b) receptor 1 (Knops blood group)
- domestic cat(101094393) complement component (3b/4b) receptor 1 (Knops blood group)
- Domestic Rabbit(100144334) complement component (3b/4b) receptor 1 (Knops blood group)
- naked mole-rat(101704987) complement component (3b/4b) receptor 1 (Knops blood group)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CD35 Antibody, clone E11, ,
Species Reactivity
human
Application
ELISA
dot blot
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
western blot
dot blot
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
western blot
Anti-CD35/CR1 Antibody, clone 2A0Q1, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-CD35-APC antibody produced in mouse, clone E11,
Species Reactivity
Application
flow cytometry
Monoclonal Anti-CD35 antibody produced in mouse, clone E11,
Species Reactivity
human, nonhuman primates
Application
flow cytometry
Anti-CR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species