ADRA2B
adrenoceptor alpha 2B
Synonyms:
ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR
Species:
Human ADRA2B (151), Mouse Adra2b (11552), Rat Adra2b (24174), cow ADRA2B (516422), naked mole-rat Adra2b (101701692), chicken ADRA2B (427631), domestic cat ADRA2B (101090432), domestic guinea pig Adra2b (100135476), Zebrafish adra2b (266751), domestic guinea pig Adra2b (100727868) ...More
UniProtKB ID:
Gene ID:
- Human(151) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011]
- Mouse(11552) adrenergic receptor, alpha 2b
- Rat(24174) adrenoceptor alpha 2B
- cow(516422) adrenergic, alpha-2B-, receptor
- naked mole-rat(101701692) adrenoceptor alpha 2B
- chicken(427631) adrenergic, alpha-2B-, receptor
- domestic cat(101090432) adrenoceptor alpha 2B
- domestic guinea pig(100135476) adrenergic receptor, alpha 2b
- Zebrafish(266751) adrenergic, alpha-2B-, receptor
- domestic guinea pig(100727868) adrenoceptor alpha 2B
- dog(611658) adrenergic, alpha-2B-, receptor
- Horse(100051684) adrenoceptor alpha 2B
- sheep(100170318) adrenoceptor alpha 2B
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Small Molecule - Agonist
Product Number
Description
Species
Tizanidine hydrochloride, 500 μg/mL in methanol, certified reference material, Cerilliant®,
Species
human
Small Molecule - Antagonist
Product Number
Description
Species
Mirtazapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Alpha 2b Adrenergic Receptor, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-ADRA2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-ADRA2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Small Molecule - Blocker
Small Molecule - Mixed Agonist/Antagonist
esiRNA
Product Number
Description
Species