- Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
Journal of medicinal chemistry (2017-11-21)
Upendra Rao Anumala, Jo Waaler, Yves Nkizinkiko, Alexander Ignatev, Katina Lazarow, Peter Lindemann, Petter Angell Olsen, Sudarshan Murthy, Ezeogo Obaji, Alexander G Majouga, Sergey Leonov, Jens Peter von Kries, Lari Lehtiö, Stefan Krauss, Marc Nazaré
PMID29155568
ABSTRACT
A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors. The identified inhibitor 16 displays high target affinity on tankyrase 1 and 2 with biochemical and cellular IC
MATERIALS