- I2-CF3SO3H synergistic promoted sp3 C-H bond diarylation of aromatic ketones.
I2-CF3SO3H synergistic promoted sp3 C-H bond diarylation of aromatic ketones.
Organic letters (2012-10-13)
Yan-ping Zhu, Feng-cheng Jia, Mei-cai Liu, Liu-ming Wu, Qun Cai, Yang Gao, An-xin Wu
PMID23057842
ABSTRACT
An I(2)-CF(3)SO(3)H synergistic promoted sp(3) C-H bond diarylation protocol was developed for the synthesis of 2,2-bis(4-(dimethylamino)phenyl)-1-aryl ethanones. The reaction performed well in the absence of any metal and ligand. It integrated three reactions with different mechanisms (iodination, Kornblum oxidation, and hydroarylation) in a single reactor.
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