- Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents.
Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents.
Chemical communications (Cambridge, England) (2011-11-02)
Bryden A F Le Bailly, Mark D Greenhalgh, Stephen P Thomas
PMID22041712
ABSTRACT
An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products of formal sp(3)-sp(3) cross-coupling reactions.
MATERIALS