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  • One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.

One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.

Molecular diversity (2009-04-22)
Victoria V Lipson, Nikolay Yu Gorobets
ABSTRACT

A general review (138 references) focused on the recent advances in the application of Meldrum's acid reactivity for synthesis of diverse pyridine and pyrimidine derivatives, mostly small and drug-like molecules is presented.

MATERIALS
Product Number
Brand
Product Description

Supelco
Pyridine solution, certified reference material, 2000 μg/mL in methanol
Sigma-Aldrich
Pyrimidine, ≥98.0%
Sigma-Aldrich
Pyridine, ≥99%
Sigma-Aldrich
2,2-Dimethyl-1,3-dioxane-4,6-dione, 98%
Supelco
Pyridine, analytical standard
Sigma-Aldrich
Pyridine, suitable for HPLC, ≥99.9%
Sigma-Aldrich
Pyridine, ACS reagent, ≥99.0%
Sigma-Aldrich
Pyridine, biotech. grade, ≥99.9%