- Enantioselective synthesis of (-)-cis-clavicipitic acid.
Enantioselective synthesis of (-)-cis-clavicipitic acid.
The Journal of organic chemistry (2007-09-20)
Jin-Mo Ku, Byeong-Seon Jeong, Sang-sup Jew, Hyeung-geun Park
PMID17877402
ABSTRACT
An enantioselective synthetic method for (-)-cis-clavicipitic acid (1) was reported. 1 was obtained in 10 steps (99% ee and 20% overall yield) from 1H-indole-3-carboxylic acid methyl ester (9) via asymmetric phase-transfer catalytic alkylation and diastereoselective Pd(II)-catalyzed intramolecular aminocyclization as key steps.