I1392
HA-100
Synonym(s):
1-(5-Isoquinolinesulfonyl)piperazine hydrochloride
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C13H15N3O2S
CAS Number:
Molecular Weight:
277.34
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
storage temp.
−20°C
SMILES string
Cl.O=S(=O)(N1CCNCC1)c2cccc3cnccc23
Gene Information
human ... MYLK(4638) , MYLK2(85366)
Biochem/physiol Actions
Inhibitor of PKA, PKC and myosin light chain kinase.
Quality
HCl content may vary.
Analysis Note
Actual content given on the label
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
M Awazu et al.
Journal of cardiovascular pharmacology, 17 Suppl 7, S500-S502 (1991-01-01)
The vasoconstrictor response is defective in diabetes mellitus (DM). Activation of protein kinase C (PKC) is also known to prevail in diabetes mellitus, and it is thought to be secondary to abnormal diacylglycerol metabolism. To ascertain whether this PKC activation
Regulation of neutrophil chemotaxis: correlations with actin polymerization.
L Harvath
Cancer investigation, 8(6), 651-654 (1990-01-01)
J T O'Flaherty et al.
Biochemical and biophysical research communications, 163(3), 1456-1460 (1989-09-29)
Three protein kinase C blockers (staurosporin, Cl, and sphinganine) acted temperature- and time-dependently on human neutrophils to lower the affinity and number of high affinity plasmalemma receptors available to leukotriene B4. The drugs did not alter the ligand's binding to
L Harvath et al.
Journal of immunology (Baltimore, Md. : 1950), 139(9), 3055-3061 (1987-11-01)
The protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine (C-I), inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol, without inhibiting superoxide release from PMN stimulated with the chemoattractants C5a or N-formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe). In this study, we
S Daniels et al.
Comparative biochemistry and physiology. Comparative physiology, 105(4), 659-665 (1993-08-01)
1. The standard O2-paradox has been studied in the Langendorff-perfused rat heart. 2. Perfusion of glucose-free saline under anoxia did not cause release of creatine kinase (CK) although, it is suggested, there was a progressive rise in [Ca2+]i. 3. Ca(2+)-depletion
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service