Skip to Content
Merck
All Photos(1)

Documents

E001

Sigma-Aldrich

Ethyl β-carboline-3-carboxylate

solid

Synonym(s):

β-CCE, Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C14H12N2O2
CAS Number:
74214-62-3
Molecular Weight:
240.26
MDL number:
MFCD00009730
UNSPSC Code:
12352103

form

solid

mp

228-230 °C (lit.)

solubility

ethanol: 3.5 mg/mL (warm)
DMSO: soluble

SMILES string

CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

InChI key

KOVRZNUMIKACTB-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Benzodiazepine inverse agonist which may be closely related to the endogenous ligand for the benzodiazepine receptor in brain.

replaced by

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

P J Cowen et al.
Nature, 290(5801), 54-55 (1981-03-05)
The mammalian central nervous system possesses specific high-affinity binding sites for the benzodiazepines and considerable evidence suggests that these binding sites are the pharmacological receptors through which these compounds act. Recently, ethyl beta-carboline-3-carboxylate (beta-CCE) has been identified in both human
P Skolnick et al.
Psychopathology, 17 Suppl 1, 25-36 (1984-01-01)
The ethyl ester of beta-carboline-3-carboxylic acid (beta-CCE) has a high affinity for benzodiazepine receptors and can antagonize some of the pharmacologic actions of benzodiazepines in rodents. Administration of beta-CCE (2.5 mg/kg) to chair-adapted, male rhesus monkeys (7-9 kg) elicited a
C Braestrup et al.
Science (New York, N.Y.), 216(4551), 1241-1243 (1982-06-11)
The gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is composed of distinct proteins embedded in the neuronal plasma membrane, is important for several effects of benzodiazepines, including protection afforded against convulsions. During structural modification of ethyl beta-carboline-3-carboxylate an agent was discovered

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service