A126
(±)-HA-966
Synonym(s):
(±)-3-Amino-1-hydroxy-2-pyrrolidone
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About This Item
Empirical Formula (Hill Notation):
C4H8N2O2
CAS Number:
Molecular Weight:
116.12
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
SMILES string
NC1CCN(O)C1=O
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Melissa Nunnink et al.
Pharmacology, biochemistry, and behavior, 87(3), 321-330 (2007-06-15)
Conditioned taste aversion (CTA) is a form of associative learning in which the pairing of a taste with a toxin causes an animal to avoid the taste. NMDA receptor mediated neurotransmission has been implicated in CTA, but the role of
Luigi Cervo et al.
Psychopharmacology, 173(1-2), 124-131 (2004-01-09)
(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in
David L Walker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(6), 2343-2351 (2002-03-16)
NMDA receptor antagonists block conditioned fear extinction when injected systemically and also when infused directly into the amygdala. Here we evaluate the ability of D-cycloserine (DCS), a partial agonist at the strychnine-insensitive glycine-recognition site on the NMDA receptor complex, to
Valéria Martinez et al.
Pain, 99(3), 537-545 (2002-10-31)
Systemic opioid dosing until adequate analgesia in neuropathic pain may involve intolerable and untreatable side effects. Peripheral opioid receptor mechanisms may participate in the antinociceptive effect of systemic morphine. We evaluated the effect of peripherally injected morphine alone, and the
J Klein et al.
Pharmacopsychiatry, 36 Suppl 1, S78-S83 (2003-09-18)
We have previously shown that hypoxia and N-methyl-D-aspartate (NMDA) receptor activation induce breakdown of choline-containing phospholipids in rat hippocampus, a process which is mediated by calcium influx and phospholipase A (2) activation. Bilobalide, a constituent of Ginkgo biloba, inhibited this
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